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We turn pioneering research into real-world impact. Our diverse portfolio of innovations is ready for licensing, collaboration, and investment—spanning diagnostics, therapeutics, biomedical devices, optical technologies and more.

Summary A new gene editing technology that offers enhanced precision and the capability to insert large DNA sequences without off-target mutations or triggering error-prone DNA repair.

Project details (pdf, 150KB)

Inventors Sandro F Ataide, Rezwan Siddiquee, Ruth Hall
Contact taylor.syme@sydney.edu.au

Summary Novel inhibitors that target the two-partner secretion system, potentially blocking the secretion of virulence factors in Gram-negative bacteria, offering a new approach to combat bacterial infections.

Project details (pdf, 150KB)

Inventors Matthew Thomas Doyle, Alfred Hartojo, Peggy Cotter, Richard Johnson
Contact taylor.syme@sydney.edu.au

Summary A novel urinary biomarker panel capable of determining the risk of PDAC in individuals with high specificity and sensitivity.

Project details (pdf, 150KB)

Inventors Sumit Sahni, Bharat Venkatesh Gundappa, Anubhav Mittal, Jaswinder Samra
Contact taylor.syme@sydney.edu.au

Summary Blood biomarker panel for the early detection of pancreatic cancer.
Inventors Sumit Sahni, Anubhav Mittal, Jaswinder Samra, Mark Molloy, Bharat Venkatesh Gundappa, Matthew J Mckay, Sooin Byeon
Contact taylor.syme@sydney.edu.au

Summary An antibody targeting Myc, with the potential to disrupt this otherwise "undruggable" target in various cancers.

Project details (pdf, 200KB)

Contact taylor.syme@sydney.edu.au

Summary A molecular diagnostic solution with over 95% specificity, leveraging DNA sequencing to objectively differentiate melanoma from benign naevi, thereby reducing the subjectivity and variability of traditional histopathology.

Project details (pdf, 250KB)

Inventors Richard A. Scolyer, Georgina Long, Ismael A. V. Correa, Andrew Colebatch, James Wilmott
Contact taylor.syme@sydney.edu.au

Summary A PSA-activated peptide sequence for prodrugs that enables targeted therapy for prostate cancer. A new approach for precision therapy for prostate cancer.

Project details (pdf, 150KB)

Inventors Trevor Hambley, Elisabeth Tondl
Contact emma-louise.hunsley@sydney.edu.au

Summary This invention is a new image reconstruction method for new generation linear accelerators that use rapid CBCT acquisition protocols.

Project details (pdf, 100KB)

Inventors Dr Mark Gardner, Dr Owen Thomas Dillon, Professor Paul Keall, Dr Hilary Byrne
Contact emma-louise.hunsley@sydney.edu.au

Summary This invention is a new copper-sensing molecular probe with applications for early diagnosis of Parkinson’s disease and management of amyotrophic lateral sclerosis.

Project details (pdf, 100KB)

Inventors Professor Elizabeth New, Professor Kay Double, Marcus Graziotto, Dr Liam Adair
Contact julius.juarez@sydney.edu.au

Summary This invention is an antivenom treatment offering a broad-spectrum solution for neutralising toxins from various sources including snakes and marine life.

Project details (pdf, 50KB)

Inventors Professor Graham Neely, Felicity Shu Yin Chung, Nicholas Casewell, Tian Du
Contact julius.juarez@sydney.edu.au

Summary This invention is a protein-based bioglue formulated to bind to neuronal tissues.

Project details (pdf, 50KB)

Inventors Dr Jingjing You, Jiawen Fan, Professor Matthew Simunovic, Professor Gerard Sutton, Dr Sheng Hua
Contact julius.juarez@sydney.edu.au

Summary A series of new ligands that exhibit significantly higher affinity for a biomarker of neuroinflammation.

Project details (pdf, 100KB)

Inventors Dr Jonathan Danon, Professor Michael Kassiou, Greta Sohler, Dr Renee Sokias, Dr Tristan Reekie, Dr Eryn Werry
Contact julius.juarez@sydney.edu.au

Summary This invention relates to new phage-drug nanoconjugates for combating bacterial infections.

Project details (pdf, 50KB)

Inventors Professor Jonathan Iredell, Dr Hien Thi Duong, Huiping Huang
Contact julius.juarez@sydney.edu.au

Summary A novel phage extracellular vesicle (EV) conjugate designed to promote tissue repair in individuals with bacterial infections.

Project details (pdf, 50KB)

Inventors Professor Wojciech Chrzanowski, Dr Hien Thi Duong
Contact julius.juarez@sydney.edu.au

Summary This invention relates to peptide mimetic compounds, inspired by the natural healing capabilities of PDGF but engineered to circumvent the pitfalls of prolonged exposure that can lead to fibrosis.

Project details (pdf, 50KB)

Inventors A/Professor James Chong, Emily McKinna, Professor Richard James Payne, Daniel Ford, Richard Harvey, Dr Osvaldo Contreras
Contact julius.juarez@sydney.edu.au

Summary A novel system designed to harness the power of directed evolution within mammalian cells.

Project details (pdf, 100KB)

Inventors Dr Daniel Hesselson, Professor Graham Gregory Neely, Dr Alexander Cole, Christopher Denes
Contact julius.juarez@sydney.edu.au

Summary This is a targeted TNBC therapy formed of an antineoplastic agent and an LHRH (Leuteinising hormone release hormone) peptide derivative which has been conjugated to an anti-mitotic agent.

Project details (pdf, 150KB)

Inventors Dr Pegah Varamini, Sepideh Khazeni
Contact julius.juarez@sydney.edu.au

Summary The innovation at hand is a nanoparticle bioconjugate that employs a dual-nanoparticle approach to target and bind to both cancer cells and immune cells.

Project details (pdf, 100KB)

Inventors A/Professor Veysel Kayser, Mariam Tarkistani
Contact julius.juarez@sydney.edu.au

Summary During chemotherapy this sensor monitors platinum complex levels for a more effective adjustment of dosages, and patient treatment plans with few side-effects.

Project details (pdf, 150KB)

Inventors Elizabeth New, Linda Mitchell, Clara Shen
Contact julius.juarez@sydney.edu.au

Summary A targeted TNBC (Triple Negative Breast Cancer) therapy with increased selectivity and efficacy and decreased toxicity.

Project details (pdf, 200KB)

Inventors Pegah Varamini, Sepideh Khazeni
Contact julius.juarez@sydney.edu.au

Summary A non-invasive device that measures multiple medical signs continuously which can be applied to blood pressure monitors, pulse oximeters, activity & fitness trackers, sleep oxygen monitors, and heart rate monitors.

Project details (pdf, 100KB)

Inventors Simon Poon, Anusha Withana
Contact julius.juarez@sydney.edu.au

Summary A board game to educate future clinicians about how different members of rural communities interact with the Australian healthcare system.

Project details (pdf, 350KB)

Inventors Heather Russell, Christopher Harrison, Lisa Hampshire, Marguerite Tracy, Annette Burgess, Matthew Tyne, Jayne Crew, Alice Henschke, Catherine Hawke
Contact emma-louise.hunsley@sydney.edu.au

Summary A number of novel transcription factors associated with functional CAR-T cell phenotypes and proliferation, and methods of identifying more.

Project details (pdf, 150KB)

Inventors Salvatore Fiorenza, Cameron Turtle
Contact emma-louise.hunsley@sydney.edu.au

Summary A novel software capable of tracking the movement of multiple targets during radiation therapy.

Project details (pdf, 150KB)

Inventors Emily Hewson, Paul Keall, Owen Thomas Dillon, Jeremy Booth
Contact emma-louise.hunsley@sydney.edu.au

Summary A novel software capable of predicting 3D lung motion with only 10 x-ray projections, for large scale lung disease screening.

Project details (pdf, 150KB)

Inventors Paul Keall, Hunor Kertesz, Owen Dillon, Hilary Byrne, Ricky O'Brien
Contact emma-louise.hunsley@sydney.edu.au

Summary A novel software to increase CT image quality thereby improving accuracy and decreasing patient radiation dose.

Project details (pdf, 150KB)

Inventors Natasha Morton, Ricky Thomas O'Brien, Paul Keall, Jeffrey Barber, Jonathan Sykes, John Kipritidis
Contact emma-louise.hunsley@sydney.edu.au

Summary Multispectral analysis of urinary biomarkers to non-invasively identify acute tubular necrosis, graft rejection, and non-rejection associated interstitial fibrosis and tubular atrophy.

Project details (pdf, 150KB)

Inventors Sonia Saad, Caroll Pollock, Ewa Goldys, Hon Lin Henry Wu, Yandong Lang
Contact emma-louise.hunsley@sydney.edu.au

Summary A small device designed to mimic the appearance of hair, capable of interfacing with the brain for sensing, actuation, and as a delivery mechanism.

Project details (pdf, 150KB)

Inventors Omid Kavehei
Contact emma-louise.hunsley@sydney.edu.au

Summary Plasma treatment to enable cell growth within a microfluidic device for greater accuracy.

Project details (pdf, 150KB)

Inventors Marcela Bilek, Jasneil Singh, Anna Waterhouse, Deepu Ashok, Shouyuan Jiang
Contact emma-louise.hunsley@sydney.edu.au

Summary Fibre sensors made of this low YM material will improve existing uses of OFS technology and open new opportunities in smart textiles, wearables, implantable therapeutic devices, healthcare, and soft robotics.

Project details (pdf, 200KB)

Inventors Professor Simon Fleming, Dr Richard Lwin, Dr Alessio Stefani, Dr Md Rejvi Kaysir
Contact jeremy.cohen@sydney.edu.au

Summary A significant advance in recycling with opportunities in areas including recycled composites for automotive, aerospace, sporting equipment, mining and defence parts, construction materials, 3D printing filaments, and consumer products.

Project details (pdf, 200KB)

Inventors Dr Ali Hadigheh
Contact lulu.xue@sydney.edu.au

Summary A technology that adds low cost and simple architecture to the existing advantages of photonics-based radar.

Project details (pdf, 50KB)

Inventors Dr Yang Liu, Mr Ziqian Zhang, Professor Benjamin Eggleton
Contact jeremy.cohen@sydney.edu.au

Summary Customising the shells, the nanoparticles’ magnetic properties can be tailored to suit specific applications in biomedicine, electronics, and sustainable and renewable energy.

Project details (pdf, 200KB)

Inventors Professor Hala Zreiqat AM, Dr Gurvinder Singh
Contact lulu.xue@sydney.edu.au

Summary A compact wearable ECG monitoring device employing AI-based deep learning algorithms for accurate, real-time diagnosis of cardiac arrhythmia.

Project details (pdf, 100KB)

Inventors Professor Branka Vucetic, Associate Professor Zihuai Lin, Xucun Yan
Contact lulu.xue@sydney.edu.au

Summary An improved protein coating process that enables covalent attachment of any protein to a glass surface without using chemical linkers or any additional reagents, which could drive growth in the global medical coatings market.

Project details (pdf, 150KB)

Inventors Professor Marcela Bilek, Dr Clara Thao Hoang Tran, Dr Stuart Tallis Fraser, Dr Badwi Bob Boumelhem, Dr Aaron Gilmour
Contact lulu.xue@sydney.edu.au

Summary An on-chip real-time versatile sensing system that can be applied to many in-situ and off-line measurement scenarios including electric vehicle battery monitoring, blood tests, and nanoparticles sensing.

Project details (pdf, 150KB)

Inventors Professor Xiaoke Yi, Dr Xiaoyi Tian
Contact lulu.xue@sydney.edu.au

Summary A revolutionary technology to help those grappling with complex communication needs.

Project details (pdf, 100KB)

Inventors Professor Alistair McEwan, Professor Petra Karlsson, Haifeng Zha
Contact lulu.xue@sydney.edu.au

Summary A framework designed to support emergency nurses in assessing and managing emergency department patients after triage.

Project details (pdf, 150KB)

Inventors Belinda Kennedy, Julie Considine, Kate Curtis, John Mackenzie, Margaret Murphy, Sarah Kourouche, Margaret Fry, Ramon Shaban
Contact taylor.syme@sydney.edu.au

Summary A custom-designed web-based platform for automating the administration of the Indigenous Tutorial Assistance Scheme-Tertiary Tuition (ITAS-TT).

Project details (pdf, 150KB)

Creators Designed at the University of Sydney by the Office of the DVC (Indigenous Strategy and Services) and developed by TechLab in Information and Communication Technology (ICT)
Contact taylor.syme@sydney.edu.au

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